Neville knows he is badly outnumbered and the odds are against him, and all the while, the infected wait for him to make a mistake that will deliver Neville into their hands.
He wanders alone through New York City, calling out for other possible survivors, and works on finding a cure for the plague using his own immune blood.
In 2012, three years after the big virus all over New York City in 2009, Robert Neville (Will Smith), a brilliant scientist, is a survivor of a man-made plague that transforms humans into bloodthirsty mutants.